Objective:To investigate the influence of Zengye Decoction and Sini Decoction on ventricle remodeling.Methods:Ventricular remodeling models were induced by injection of isoproterenol in mice and constriction of abdominal aorta in rats.The effects of Zengye Decoction and Sini Decoction on the heart weight index

blood pressure

AngⅡ

ALD

ET and Hyp levels were assessed.Results:Compared with those of the normal or sham operated group

the heart weight index

blood pressure

the levels of AngⅡ

ET

Hyp in the myocardium and ALD in the blood serum were significantly increased in the model group.In group treated with Zengye Decoction

the heart weight index

blood pressure

the levels of AngⅡ

ET

Hyp in the myocardium and the serum level of ALD were decreased remarkably.Sini Decoction did not show such effects

except that it could decline the level of ET.Conclusions:Zengye Decoction has the effects on inhibiting ventricular remodeling.The mechanism may be related to decreasing the blood pressure and inhibiting neuroendocrine factors.Sini Decoction has no effects on inhibiting ventricular remodeling.