洋金花治疗银屑病有效部位的药理作用研究(Ⅰ)——抗炎、抗瘙痒及抗过敏作用

王秋红; 肖洪彬; 杨炳友; 姚凤云; 匡海学

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洋金花治疗银屑病有效部位的药理作用研究(Ⅰ)——抗炎、抗瘙痒及抗过敏作用

更新时间：2024-01-04

- 洋金花治疗银屑病有效部位的药理作用研究(Ⅰ)——抗炎、抗瘙痒及抗过敏作用
- Studies on Pharmacological Actions of the Effective Parts for Psoriasis in Flos Daturae(Ⅰ)——The Anti-inflammatory,Anti-titillation and Anti-anaphylaxis Actions of Flos daturae
- 中国实验方剂学杂志 2008年14卷第2期页码：49-51
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家重点基础研究发展计划资助课题(2006CB504708);国家自然科学基金资助课题(30672633)
- DOI：
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- 纸质出版日期：2008
- 稿件说明：
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王秋红, 肖洪彬, 杨炳友, 等. 洋金花治疗银屑病有效部位的药理作用研究(Ⅰ)——抗炎、抗瘙痒及抗过敏作用[J]. 中国实验方剂学杂志, 2008,14(2):49-51.

WANG Qiu-hong, XIAO Hong-bin, YANG Bing-you, et al. Studies on Pharmacological Actions of the Effective Parts for Psoriasis in Flos Daturae(Ⅰ)——The Anti-inflammatory,Anti-titillation and Anti-anaphylaxis Actions of Flos daturae[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 49-51.
王秋红, 肖洪彬, 杨炳友, 等. 洋金花治疗银屑病有效部位的药理作用研究(Ⅰ)——抗炎、抗瘙痒及抗过敏作用[J]. 中国实验方剂学杂志, 2008,14(2):49-51. DOI：

WANG Qiu-hong, XIAO Hong-bin, YANG Bing-you, et al. Studies on Pharmacological Actions of the Effective Parts for Psoriasis in Flos Daturae(Ⅰ)——The Anti-inflammatory,Anti-titillation and Anti-anaphylaxis Actions of Flos daturae[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 49-51. DOI：

摘要

目的:阐明洋金花治疗银屑病有效部位的抗炎、抗瘙痒及抗过敏作用。方法:以二甲苯致小鼠耳肿胀法和10%蛋清致大鼠足肿胀法进行抗炎作用研究;用0.35%磷酸组织胺刺激豚鼠皮肤考察抗搔痒作用;以氯化乙酰胆碱和组织胺混合液引起的豚鼠喘息性抽搐为指标考察抗过敏作用。结果:洋金花治疗银屑病有效部位可明显抑制二甲苯引起的小鼠耳肿胀和蛋清引起的大鼠足肿胀;可使组织胺所致豚鼠皮肤搔痒的组织胺用量明显增加;对乙酰胆碱和组织胺混合液所引起的豚鼠变态反应性哮喘的发作潜伏期明显延长。结论:洋金花治疗银屑病有效部位具有较强的抗炎、抗皮肤瘙痒及抗过敏等药理作用。

Abstract

Objective:To elucidate the anti-inflammatory

anti-titillation of skin

anti-anaphylaxis actions of the effective parts in Flos Daturae.Methods:The anti-inflammatory and anti-titillation action on swelling ear of mice induced by xylene and swelling toe of rat induced by 10% OVA;and on cavia cobaya skin induced by 0.35% histamine phosphate respectively.Antianaphylaxis action was observed on cavia cobaya according to the index of gasping twitch caused by the miscible liquids of acetylcholine and histamine.Results:The effective parts of Flos Daturae remarkably inhibited the ear swelling

increased histamine dosage which lead to skin itching of cavia cobaya

evidently extended delitescence of allergic asthma on cavia cobaya caused by the miscible liquids of acetylcholine and histamine.Conclusions:The effective parts of Flos Daturae have many obvious pharmacological actions

including anti-inflammatory

anti-titillation of skin and antianaphylaxis actions.

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