DONG Wei, LIANG Ai-hua, XUE Bao-yun, et al. Cholagogic Effect and Hepatoprotective Effect of Longdan Xiegan Pill (with Caulis Akebial Australis) on Experimental Cholestasis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 37-40.
DONG Wei, LIANG Ai-hua, XUE Bao-yun, et al. Cholagogic Effect and Hepatoprotective Effect of Longdan Xiegan Pill (with Caulis Akebial Australis) on Experimental Cholestasis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 37-40.DOI:
Objective:To investigate the cholagogic effect and hepatoprotective effect of Longdan Xiegan Pill on the Cholestasis model in mice.Methods:The cholestasis model was induced by percutaneous 100 mg·kg-1 α-Naphthyl isothiocyanate(ANIT).Bile flow
the levels of AST
ALT
ALP
TBIL
DBIL
CHO
SOD
MDA
GSH inserum and TBIL
DBIL
CHO in the bile were measured.Pathological changes of the liver tissue were observed under opticmicroscope.Results:Longdan Xiegan Pill(with Caulis Akebiale Australis) significantly highered Bile flow and markedly ameliorated the liver damage(P<0.05).Conclusion:Longdan Xiegan Pill(with Caulis Akebial Australis) can protect against cholestasis induced by ANIT in mice.