六味地黄丸血中移行成分对氢化可的松致大鼠肾虚动物模型的保护作用

王喜军1; 张宁1; 孙晖1; 李丽静2; 吕海涛1

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六味地黄丸血中移行成分对氢化可的松致大鼠肾虚动物模型的保护作用

更新时间：2024-01-04

- 六味地黄丸血中移行成分对氢化可的松致大鼠肾虚动物模型的保护作用
- Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat
- 中国实验方剂学杂志 2008年14卷第2期页码：33-37
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(30572300)
- DOI：
  中图分类号：
- 纸质出版日期：2008
- 稿件说明：
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王喜军1, 张宁1, 孙晖1, 等. 六味地黄丸血中移行成分对氢化可的松致大鼠肾虚动物模型的保护作用[J]. 中国实验方剂学杂志, 2008,14(2):33-37.

WANG Xi-jun1, ZHANG Ning1, SUN Hui1, et al. Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 33-37.
王喜军1, 张宁1, 孙晖1, 等. 六味地黄丸血中移行成分对氢化可的松致大鼠肾虚动物模型的保护作用[J]. 中国实验方剂学杂志, 2008,14(2):33-37. DOI：

WANG Xi-jun1, ZHANG Ning1, SUN Hui1, et al. Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 33-37. DOI：

摘要

目的:通过研究六味地黄丸血中移行成分对氢化可的松致大鼠肾虚动物模型的保护作用

阐明六味地黄丸补肾的药效物质基础。方法:70只大鼠随机分为空白组、模型组、总组分组、混合组分组、5-羟甲基-2-糠酸(5-HMFA)组、丹皮酚组和六味组共7个实验组

按5mL/kg体重连续9d分别灌胃给予蒸馏水、蒸馏水、总组分药液、混合组分药液、5-HMFA药液和丹皮酚药液;第5～9天

除空白组皮下注射生理盐水外

其他各组按5mL/kg体重每天皮下注射氢化可的松注射液25mg/kg

于实验的第10天测定体重等10项评价指标。结果:与模型组相比

各给药组动物的检测指标均有明显改善

其中莫诺苷、獐牙菜苷、马钱子苷的混合物组作用最显著。结论:初步确定所分离得到的六味地黄丸的血中移行成分是六味地黄丸补肾的药效物质基础

其中以莫诺苷

獐牙菜苷和马钱子苷的作用最为明显

是补肾的核心成分。

Abstract

Objective:To elucidate bioactive constituents for invigorating the kidney in Liuwei Dihuang Wan based on study on protective effect of Liuwei Dihuang Wan and its constituents absorbed into blood after oral administration on hydrocortisone inducing renal deficiency in rat.Method: Seventy rats were randomly divided into seven groups including control

model

total components

5-HMFA

mixture containing morroniside

sweroside and loganin

paeonol and LW group.For continous 9 days

every group rat was respectively orally administrated with distilled water

distilled water

total components

5-HMFA mixture containing morroniside

sweroside and loganin

paeonol and LW

from 5 day to 9 day

control group rat was subcutaneously injected with sodium chloride at a dose of 5 ml/kg body weight

the other groups rat was subcutaneously injected with hydrocortisone at a dose of 25 mg/kg body weight(5 ml/kg).On 10th day

collected samples for analyzing 10 batches of indexes.Result: Every group drugs all improved such 10 batches of indexs in a large

the effect of mixture containing morroniside

sweroside and loganin group is most significantly.Conclusion: It is found that determined constituents absorbed into blood after oral administration of Liuwei Dihuang Wan is mainly bioactive constituents for invigorating the kidney

and the bioactivities of morroniside

sweroside and loganin is most perferred.

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