Objective:To observe the influence of Xuefuzhuyu Granule(XFZHYG) on coronary circulation and serum enzymes of acute myocardial ischemia in anesthetized dogs.Methods:Twenty-four dogs were devided at random into four groups:(1) model group(2)XFZHYG 5.0 g·kg-1 group(3)XFZHYG 2.5 g·kg-1 group(4)XFZHYG 5.0 g·kg-1 group.The parameters of the coronary circulation and the changes of the enzymes in serum were determined by using the acute myocardial ischemia model of left anterior descending branch(LAD) in the anaesthetized dogs.Results:The coronary resistance(P<0.05) was decreased

the myocardial blood flow was increased(P<0.05) in dogs treated with XFZHYG of 2.5

5.0 g·kg-1.The activities of serum LA

FFA and MDA were decreased(P<0.01

P<0.05)

the SOD and GSH-Px were increased(P<0.05) in acute myocardial ischemia dogs treated with of XFZHYG 2.5

5.0 g·kg-1.Conclusion:XFZHYG has protective effect on myocardial ischemia through the changes in serum enzymes

decreasing coronary vascular resistance and increasing the myocardial blood flow in dogs.