肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响

孙杰; 赵鸿亮; 王俊霞; 吴立文

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肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响

更新时间：2024-09-23

- 肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响
- Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease
- 中国实验方剂学杂志 2007年13卷第9期页码：37-40
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- 基金信息：
  
  甘肃省中医管理局(2004-GZK-07)
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- 纸质出版日期：2007
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孙杰, 赵鸿亮, 王俊霞, 等. 肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响[J]. 中国实验方剂学杂志, 2007,13(9):37-40.

SUN Jie, ZHAO Hong-liang, WANG Jun-xia, et al. Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(9): 37-40.
孙杰, 赵鸿亮, 王俊霞, 等. 肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响[J]. 中国实验方剂学杂志, 2007,13(9):37-40. DOI：

SUN Jie, ZHAO Hong-liang, WANG Jun-xia, et al. Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(9): 37-40. DOI：

摘要

目的:探讨肺心通对慢性肺源性心脏病(CPHD)模型大鼠的治疗效果及作用机理。方法:Wistar大鼠用野百合碱(MCT

60mg·kg-1)1次腹腔注射复制CPHD大鼠模型

以肺心通混悬液治疗

21d后

行支气管肺泡灌洗液(BALF)细胞总数及分类计数

测定大鼠血清、肺组织匀浆、肺泡灌洗液(BALF)中白介素8(IL-8)、肿瘤坏死因子α(TNF-α)的含量

肺组织切片在光镜、电镜下观察病理形态改变。结果:经治疗后

肺心通混悬液对上述检测指标的水平有明显抑制作用(P<0.01或P<0.05)

在光、电镜下观察对大鼠肺血管内皮细胞的损伤有一定的修复作用。结论:肺心通药物对CPHD大鼠有较好的治疗作用。

Abstract

Objective:To research the effect and the mechanism of Feixintong on rat model of chronic pulmonary heart disease(CPHD).Methods:50 Wistar rats were randomly divided into five groups.Rats were given a single injection of monocrotaline(MCT

60 μg/g)to induce the model of CPHD.The Feixintong groups were treated by suspension in 21 days

then total white cell counts and differential counts and interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)were examined.Lung organism slices were observed with microscope.Results:The examined items of the Feixintong groups were lower than the model groups(P<0.01 or P<0.05)

endotheliocytes were repaired by Feixintong.Conclusions:Feixintong has good efficacy for treatment of rat model of CPHD.

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