智脑胶囊对血管性痴呆模型大鼠学习记忆及脑组织Ca含量的影响

杨文明; 王时光; 鲍远程; 杨兴涛; 张波; 汪美霞; 董婷

您当前的位置：

首页 >

文章列表页 >

智脑胶囊对血管性痴呆模型大鼠学习记忆及脑组织Ca含量的影响

更新时间：2024-01-04

- 智脑胶囊对血管性痴呆模型大鼠学习记忆及脑组织Ca含量的影响
- The Effect of Capsule on Learning-memory Ability and the Content of Ca in Brain Tissue of Rats with Vascular Dementia
- 中国实验方剂学杂志 2007年13卷第12期页码：34-37
- 作者机构：
- 作者简介：
- 基金信息：
  
  安徽省教育厅自然科学基金(99JLZC138);安徽省人才开发基金(20032026);安徽省优秀青年科技基金(科金200203)
- DOI：
  中图分类号：
- 纸质出版日期：2007
- 稿件说明：
移动端阅览
杨文明, 王时光, 鲍远程, 等. 智脑胶囊对血管性痴呆模型大鼠学习记忆及脑组织Ca含量的影响[J]. 中国实验方剂学杂志, 2007,13(12):34-37.

YANG Wen-ming, WANG Shi-guang, BAO Yuan-cheng, et al. The Effect of Capsule on Learning-memory Ability and the Content of Ca in Brain Tissue of Rats with Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(12): 34-37.
杨文明, 王时光, 鲍远程, 等. 智脑胶囊对血管性痴呆模型大鼠学习记忆及脑组织Ca含量的影响[J]. 中国实验方剂学杂志, 2007,13(12):34-37. DOI：

YANG Wen-ming, WANG Shi-guang, BAO Yuan-cheng, et al. The Effect of Capsule on Learning-memory Ability and the Content of Ca in Brain Tissue of Rats with Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(12): 34-37. DOI：

摘要

目的:探讨智脑胶囊对血管性痴呆大鼠学习记忆及脑组织Ca2+含量的影响。方法:反复夹闭双侧颈总动脉(CCA)结合腹腔注射硝普钠降低血压制备血管性痴呆大鼠模型

检测大鼠学习记忆能力及脑组织中Ca2+含量。结果:血管性痴呆模型组大鼠学习记忆明显障碍

脑组织中Ca2+浓度明显升高。与模型组相比

智脑胶囊3剂量组、尼莫地平组及脑复康组能够明显减少血管性痴呆模型大鼠脑组织中Ca2+含量(P<0.05或P<0.01)。智脑胶囊高剂量与智脑胶囊低、中剂量组比较能明显降低模型大鼠脑组织Ca2+含量

且有统计学意义(P<0.05)。结论:智脑胶囊可改善实验性血管性痴呆大鼠学习记忆能力

其机制与降低模型大鼠脑组织Ca2+含量有关。

Abstract

Objective:To investigate the effect of Zhinao Capsule on behavior and the content of Ca2+ in brain tissue of rats with vascular dementia.Methods:After intraperitoneal injection of low dose of sodium nitroprusside

animal models of vascular dementia were established by clamping common carotid arteries repeatedly.Their learning and memory ability and the content of Ca2+ in brain tissue of rats were detected.Results:The learning and memory ability had been reduced obviously in the model group of rats with vascular dementia

and the content of Ca2+ in brain tissue had been increased.Compared with model group

three kinds of Zhinao Capsule treated group

nimodipine treated group and piracetam treated group could significantly decrease the content of Ca2+ in brain tissue of rats with vascular dementia(P<0.05 or P<0.01).The content of Ca2+ in brain tissue of rats with vascular dementia could decrease more in high dose of Zhinao capsule treated group than in other two groups(P<0.05).Conclusions:Zhinao Capsule could improve the learning and memory in rats with vascular dementia

which may be related to decreasing the content of Ca2+ in brain tissue of rats.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

智脑胶囊治疗血管性痴呆60例临床研究

智脑胶囊对血管性痴呆模型大鼠行为学及脑组织NO、ET、CGRP含量的影响

黄连解毒汤调控FBXL5/IRP2改善VaD小鼠脑铁代谢紊乱、髓鞘损伤及激越攻击行为

基于HIF-1α/BNIP3信号通路调控线粒体自噬探讨通脉开窍丸治疗血管性痴呆大鼠的机制