肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响

孙杰; 王俊霞; 赵鸿亮; 吴立文

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肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响

更新时间：2024-09-23

- 肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响
- Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease
- 中国实验方剂学杂志 2007年13卷第8期页码：36-38
- 作者机构：
- 作者简介：
- 基金信息：
  
  甘肃省中医管理局资助课题(2004-GZK-07)
- DOI：
  中图分类号：
- 纸质出版日期：2007
- 稿件说明：
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孙杰, 王俊霞, 赵鸿亮, 等. 肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响[J]. 中国实验方剂学杂志, 2007,13(8):36-38.

SUN Jie, WNAG Jun-xia, ZHAO Hong-liang, et al. Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 36-38.
孙杰, 王俊霞, 赵鸿亮, 等. 肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响[J]. 中国实验方剂学杂志, 2007,13(8):36-38. DOI：

SUN Jie, WNAG Jun-xia, ZHAO Hong-liang, et al. Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 36-38. DOI：

摘要

目的:探讨肺心通对慢性肺源性心脏病(CPHD)大鼠的治疗效果及其作用机理。方法:50只Wistar大鼠

雌雄各半

随机分为空白组、模型组、肺心通高、中、低剂量组

以2%野百合碱(MCT)按60mg/kg1次腹腔注射复制CPHD大鼠模型。同时给模型组、肺心通高、中、低剂量组灌胃相应药物

连续用药21d。测定大鼠血清和肺组织匀浆中一氧化氮(NO)、内皮素-1(ET-1)的含量;测定肺小动脉及支气管平滑肌血管内皮细胞生长因子(VEGF)的表达;观察肺组织病理形态学改变。结果:肺心通可显著提高CPHD模型大鼠的NO含量;降低ET-1的含量;降低大鼠肺小动脉及支气管平滑肌中VEGF的表达;改善肺组织的病理改变。结论:肺心通对CPHD大鼠有较好的治疗作用。

Abstract

Objective:To research the functionary mechanism and treating effect of Feixintong(FXT) on chronic pulmonary heart disease(CPHD).Methods:50 Wister rats were randomly separated into five groups:blank control group

model group

FXT groups of high

middle and low dosage

The rat model of corpulmonale was established by injecting 2% monocrotaline(60 mg/kg)i.p.At the same time

model group

FXT groups of high

middle and low dosage were separately administrated with physical saline or FXT for 21 days.NO

ET-1 and expression of VEGF in bronchi arterioles was measured.Lung tissue sections were examined to study the morphological alternations.Results:FXT could evidently improve the NO content of rat model of CPHD;reduce the ET-1 content;reduce the expression of VEGF in bronchi arterioles.Conclusions:FXT treatment is effective on rat model of CPHD.

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肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响