Objective:To study the anti-duck Hepatitis B virus(DHBV) action of protoporphyrin disodium(PPN).Methods: Longyan ducks with congenital infection of HBV were used as the animal model and the each group of ducks was given the drug with the doses 20 mg·kg-1·d-1 for 10 successive days.DHBV-DNA in serum was detected by dot-hybridization test before treatment

5 days and 10 days after treatment

the pathological changes of the duck liver were also examined by HE staining.Results: After giving medication with PPN for 5 days and for 10 days

the optic density value of DHBV-DNA in ducks serum were obviously lower than that before treated(1.36±0.26

1.05±0.28 VS 2.04±0.05

1.90±0.31)

there were remarkable difference(P<0.01

P<0.05).Spotty hepatocyte necroses in treatment group was improved more obviously than that in model group.Conclusion: PPN can protect duck liver against inflammation by the inhibition of DHBV.