Objective:To investigate the effect of Gongning Granule on uterus haemorrhage induced by drug-abortion in mice and rats.Methods:Pregnant mice or rats were intragastrically(ig) administrated with mifepristone 8 mg/kg in rats or 12 mg/kg in mice at day 7 postgestational to induce uterus haemorrhage.The mice or rats were treated with Gongning Granule ig at doses of 3

6

12 g crude drug/kg body weight

once a day for consecutive 5 days.The amount of uterus haemorrhage of mice and rats

bleeding time and clot time of mice

PT

TT and APTT of rats were tested.Results: Gongning Granule of 6

12 g/kg decreased the amount of uterus haemorrhage of mice and rats

shortened the PT and TT of rats.The results indicated that Gongning Granule has an obvious hemostasia effect.Conclusion: Gongning Granule have an obvious hemostasia effect on uterus haemorrhage induced by drug-abortion.