Objective:To study the regulating effect and the mechanism of Wendan decoction on disorder of lipid metabolism in rat.Methods:The model rats of disorder of lipid metabolism have been established by feeding high-fat emulsion Ocally.The regulating effects of Wendan decoction on triglyceride(TG)

total cholesterol(TG)

super oxide dismutase(SOD)

malondialdehyde(MDA)

lipoprotein lipase(LPL)

hepatic lipase(HL)

total lipase(LA) in serum of the rats were observered.Result:Wendan decoction reduced the levels of TC

TG of the modal rats

compared with the model group the differences are P<0.01 and P<0.05.Wendan decoction raised SOD and reduced MDA

P<0.05 and P<0.01.At the same time

Wendan decoction could raise the activity of LA and LPL

P<0.01.but there was no effect on HL.Conclusion:Wendan decoction can regulate the disorder of lipid metabolism by raising the activity of LA and LPL in the modal rats effectively

and it may reduce the degree of lipid peroxidation and cell damage.