甘草提取物缓释微丸制备体外释放考察

李俊松; 冯怡; 徐德生

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甘草提取物缓释微丸制备体外释放考察

更新时间：2024-01-04

- 甘草提取物缓释微丸制备体外释放考察
- The Preparation and Drug Release Test of Glycyrrhizae Extracts Coated Sustained Release Pellets
- 中国实验方剂学杂志 2007年13卷第10期页码：11-14
- 作者机构：
- 作者简介：
- 基金信息：
  
  上海市科委资助项目“芍药甘草复方释药系统基础研究”(No:04DZ19841)
- DOI：
  中图分类号：
- 纸质出版日期：2007
- 稿件说明：
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李俊松, 冯怡, 徐德生. 甘草提取物缓释微丸制备体外释放考察[J]. 中国实验方剂学杂志, 2007,13(10):11-14.

LI Jun-song, Feng Yi, XU De-sheng. The Preparation and Drug Release Test of Glycyrrhizae Extracts Coated Sustained Release Pellets[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 11-14.
李俊松, 冯怡, 徐德生. 甘草提取物缓释微丸制备体外释放考察[J]. 中国实验方剂学杂志, 2007,13(10):11-14. DOI：

LI Jun-song, Feng Yi, XU De-sheng. The Preparation and Drug Release Test of Glycyrrhizae Extracts Coated Sustained Release Pellets[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 11-14. DOI：

摘要

目的:制备甘草提取物缓释微丸

考察不同包衣条件下甘草提取物缓释微丸的体外释放。方法:采用单因素实验优选包衣工艺。结果:以丙烯酸树脂Eudragit RL100为包衣材料

包衣增重5%(w·w-1)

增塑剂的用量为10%(w·w-1)

可满足12h缓释的要求。结论:包衣量、PEG6000量是影响药物释放的关键因素。

Abstract

Objective:To prepare glycyrrhizae extracts coated sustained release pellets and study the drug release in vitro under different coating conditions.Methods:A single factor design experiment was applied to optimize the formulation of coated sustained release pellets.Results:A satisfactory 12 h sustained release curve can be obtained when the pellets is coated with Eudragit RS100 5%(w·w-1) and PEG6000 10%(w·w-1) under the optimized formulation.Conclusions:The increased weight and proportion of Eudragits RS100 and PEG6000 are the main factors which influence the drug release.

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