QIAN Hui-nan, HU Xue-qin, SHEN Li-bo, et al. The Influence of Invigorating Spleen and Restoring Virility on the Arginine Vasopressin Level in Brain and Gene Expression[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(11): 30-32.
QIAN Hui-nan, HU Xue-qin, SHEN Li-bo, et al. The Influence of Invigorating Spleen and Restoring Virility on the Arginine Vasopressin Level in Brain and Gene Expression[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(11): 30-32.DOI:
Objective:To Study the influence of invigorating spleen and restoring virility to the AVP level in brain and gene expression.Method:Establishing the spleen insufficiency model of rat by adopting bitter decline diarrhea
wild eating and overworking
the hypothalamus ventral kernel
the hippocampi CA1 area and forehead cortex
the gene expression change of AVP were examined.Result:In the model group
the immunoreaction masculine substance of AVP
hypothalamus ventral kernel
hippocampi CA1 area and prefrontal cortex decreases obviously;The immunoreaction masculine substance of AVP on above mentioned parts in the group of invigorating spleen and restoring virility increases distinctly.In the model group
the expression of AVP mRNA on hypothalamus ventral kernel
hippocampi CA1 area and prefrontal cortex decreases obviously;While for the groups of invigorating spleen and restoring virility
they increases obviously.Conclusion:Invigorating spleen and restoring virility may affect study and memory ability by regulating the AVP level and gene expression.