Objective:To study the antihyperlipidemia effect of allicin and the mechanism.Methods:50 mice were divided into five groups:control group

hyperlipidmia

small

medium and large dose groups of allicin with hyperlipidemia.Levels of TG

TC

HDL-C

LDL-C

lecithin cholesterol acyltransferase(LCAT)

lipoprotein lipase of heart(LPL)

hepatic lipase(HL)and 3-hydroxy-3-methylglutaryl-CoA(HMGCoA) reductase were measured.The experiment on particle of cholesterol in vitro was performed.Results:Allicin has obvious effects of reducing the contents of TG

TC

LDL-C and increasing the content of HDL-C.Allicin can

to some extent

increase the activities of LCAT

LPL and HL

and decrease the activity of liver HMGCoA reductase in vitro.Allicin also can inhibit the particle of cholesterol in vitro.Conclusion:Allicin obviously decreased the blood lipids.The mechanisms of reducing blood lipids perhaps were to promote the metabolism and change of the lipoprotein

inhibit absorbing cholesterol and reduce cholesterol biosynthesis as well as enhance TG decomposition in the mice serum and liver.