从药物转运体入手开展中药配伍治疗脑病的思路探索

王冰; 潘彦舒; 李澎涛

您当前的位置：

首页 >

文章列表页 >

从药物转运体入手开展中药配伍治疗脑病的思路探索

更新时间：2024-01-04

- 从药物转运体入手开展中药配伍治疗脑病的思路探索
- Exploration of Thoughts on the Compatibility of Traditional Chinese Medicine Curing Encephalopathy by the Employment of Drug Transporters
- 中国实验方剂学杂志 2007年13卷第4期页码：60-63
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目(No:30300469);国家“973”资助项目(2005CB523311)
- DOI：
  中图分类号：
- 纸质出版日期：2007
- 稿件说明：
移动端阅览
王冰, 潘彦舒, 李澎涛. 从药物转运体入手开展中药配伍治疗脑病的思路探索[J]. 中国实验方剂学杂志, 2007,13(4):60-63.

WANG Bing, PAN Yan-shu, LI Peng-tao. Exploration of Thoughts on the Compatibility of Traditional Chinese Medicine Curing Encephalopathy by the Employment of Drug Transporters[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 60-63.
王冰, 潘彦舒, 李澎涛. 从药物转运体入手开展中药配伍治疗脑病的思路探索[J]. 中国实验方剂学杂志, 2007,13(4):60-63. DOI：

WANG Bing, PAN Yan-shu, LI Peng-tao. Exploration of Thoughts on the Compatibility of Traditional Chinese Medicine Curing Encephalopathy by the Employment of Drug Transporters[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 60-63. DOI：

摘要

目前

针对脑血管疾病的治疗措施仍显力不从心

其主要原因是由于血脑屏障使得受损脑组织无法获得有效的药物浓度

因此促进有效药物的脑部转运便成为一个亟待解决的关键问题。而已知开启血脑屏障增加药物脑内浓度的方法均存在一定局限性

未能真正有效地应用于临床。由于中药配伍应用能发挥多环节、多靶点的作用

使其在脑系疾病的治疗中显示出明显的优势。因此

在中药复方配伍理论的指导下

从脑部药物转运体入手

开展中药有效组分配伍应用特异性的研究

有效地开启血脑屏障转运功能以提高药物进入脑组织的能力

可为突破脑病治疗药物开发的瓶颈提供新的思路。

Abstract

Now the therapeutic measures for cerebrovascular disease still remain unable to fulfil the goal.The main reason is that the damage of brain tissue can not obtain the effective drug level due to the prevention of blood-brain barrier(BBB).So it is an urgently key problem for us to promote active drug into brain.And because the current methods of opening BBB

even may increase drug level in the brain

invariably have limitations.They can not be really utilized in the clinic efficiently.However

the compatibility of traditional Chinese medicine has an advantage for the treatment of encephalopathy

since it possesses poly-link and multi-target protection.So with the guidance of the theory of compatibility of traditional Chinese medicine it is very significant for us to explore that the compatibility of active principles may effectively open BBB

with enhancing drug transport into brain.It is a new thought for the breakthrough of the bottleneck of curing encephalopathy.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

基于DCE-MRI评价协定方通脑饮改善急性缺血性脑卒中患者血脑屏障损伤的疗效

小檗碱类成分对乙酰胆碱酯酶的抑制作用及血脑屏障透过性分析

红景天苷对脑缺血损伤的保护作用及机制研究进展

基于脑玄府理论探讨中药引经及配伍思路

三化汤及其拆方对大鼠脑缺血再灌注损伤的保护作用及机制