补肾活血化痰中药复方对D-半乳糖诱发衰老模型大鼠中枢神经递质及β-淀粉样蛋白的影响

熊平; 蒋灵芝1; 黄兆胜2

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补肾活血化痰中药复方对D-半乳糖诱发衰老模型大鼠中枢神经递质及β-淀粉样蛋白的影响

更新时间：2024-01-04

- 补肾活血化痰中药复方对D-半乳糖诱发衰老模型大鼠中枢神经递质及β-淀粉样蛋白的影响
- Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose
- 中国实验方剂学杂志 2007年13卷第2期页码：42-45
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  校基金2005K151
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- 纸质出版日期：2007
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熊平, 蒋灵芝1, 黄兆胜2. 补肾活血化痰中药复方对D-半乳糖诱发衰老模型大鼠中枢神经递质及β-淀粉样蛋白的影响[J]. 中国实验方剂学杂志, 2007,13(2):42-45.

XIONG Ping, JIANG Ling-zhi1, HUANG Zhao-sheng2. Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 42-45.
熊平, 蒋灵芝1, 黄兆胜2. 补肾活血化痰中药复方对D-半乳糖诱发衰老模型大鼠中枢神经递质及β-淀粉样蛋白的影响[J]. 中国实验方剂学杂志, 2007,13(2):42-45. DOI：

XIONG Ping, JIANG Ling-zhi1, HUANG Zhao-sheng2. Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 42-45. DOI：

摘要

目的:研究补肾活血化痰中药对皮质乙酰胆碱酯酶(AchE)活性和β-淀粉样蛋白(β-AP)含量的影响

阐释传统中药复方改善老年性痴呆的作用机制。方法:腹腔注射D-半乳糖合并脑内双侧Meynert基底核注射鹅膏蕈胺酸(IBO)建立AD大鼠模型

用放射免疫技术、免疫组化检测皮质AchE的活性和脑内β-AP蛋白含量。结果:补肾活血化痰中药大剂量组皮质AchE的活性显著较模型组高(P<0.01)

而脑内β-AP含量低于模型组(P<0.05)。结论:中药大剂量组通过降低海马β-AP含量(P<0.05)

提高AchE活性来恢复记忆能力。

Abstract

Objective:To investigate the influences of the Chinese prescription of reinforcing the kidney

activating blood circulation and resolving phlegm on cerebral AchE and β-AP in senile dementia model of rat induced by D-galactose.Method:Senile dementia model of rat was established by intraperitoneal injection of D-galactose combined with injection of goose paste gill fungus amino acid(IBO) at bilateral Meynert basal nucleus.AchE and β-AP were determined by radio-immunological and histo-immunological techniques.Results:Compared with the model group

AchE in cerebral cortex was significantly increased in the large dose group of the Chinese prescription (P<0.01)

while the β-AP was decreased(P<0.05).Conclusion:The Chinese prescription may enhance AchE activity to restore the memory ability by reducing β-AP level.

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