YU Hao1, LIU Hai-peng2. Effect of Cortex Moutan Polysaceharide-2b on Early Diabetic Nephropathy in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 36-38.
YU Hao1, LIU Hai-peng2. Effect of Cortex Moutan Polysaceharide-2b on Early Diabetic Nephropathy in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 36-38.DOI:
Objective:To observe the effect of Cortex Moutan polysaccharide-2b (CMP-2b) on early diabetic nephropathy(DN) in rats.Methods:The rat model of DN was induced by injecting complete freunds adjuvant(CFA) and streptozotocin(STZ) intraperitoneally.The ratio of kidney weight to body weight
the glomerular filtration rate(GFR)
the urine microalbumin(MALB)
α1-microglobulin(α1-MG)
urine N-acetyl-beta-D-amidogen glucosamindase(NAG) and the kidney ultrastructure were observed.Results:The results showed CMP-2b could significantly decrease the ratio of kidney weight to body weight and GFR
reduce the level of urine MALB
α1-MG and NAG
and improve the pathological change of kidney in DN rats.Conclusion:CMP-2b has the therapeutic effects on early DN in rats.