ZHEN Han-shen, LIANG Jie, Zhou Fang. Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 32-34.
ZHEN Han-shen, LIANG Jie, Zhou Fang. Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 32-34.DOI:
Objective:To study the anti-hyperglycemic effect of Gymnema sylvestre(Retz.)Schult 95% Ethanolic Extracts(GSEE).Method:Normal mice
alloxan-induced diabetic mice
adrenaline-induced hyperglycemic mice were used.The anti-hyperglycemic action was studied with radio-immunoassay and glucoseoxidase.Result:High dosage of GSEE could decrease fasted blood sugar in normal mice.It could increase serum insulin level
decrease fasted blood sugar in alloxan-induced diabetic mice.It could also decrease fasted blood sugar in adrenaline-induced hyperglycemic mice.It could improve glucose tolerance in normal mice
and the duration was about 1 hour.Conclusion:GSEE has obvious anti-hyperglycemic effect in alloxan-induced diabetic mice and adrenaline-induced hyperglycemic mice.It could improve glucose tolerance in normal mice.Its mechanism is stimulating of insulin secretion from β cells.