Objective:To observe the influence of Gegen compound on neuroendocrine and ethology of posttraumtic stress disorder in rats.Methods:The model of rat posttraumtic stress disorder was used.RIA was used to determine the levels of corticosterone(CORT) and adrenocortlcotrophic hormone(ACTH).The influence of rat posttraumtic stress disorder on ethology were studied with Open-field test and tail hang test.Results:The CORT and ACTH contents of rats with PTSD are respectively(16.76±2.33)ng/mL and(101.21±22.07)pg/mL.The values of crossing and rearing are(26.2±8.4) and(8.5±3.5)

motionless time is(227.00±50.13)s.The CORT contents of Gegen compound high

medium and low dosage are(8.69±2.47)

(10.32±2.12) and(12.03±3.06) ng/mL.The ACTH contents are(66.63±15.34)

(77.49±14.63) and(87.93±12.16)pg/mL.The values of crossing are(60.3±13.6)

(47.0±11.6)和(34.3±8.2).The values of rearing are (24.0±5.5)

(20.9±5.8) and(11.5±4.4)

motionless time are(164.60±46.50)

(178.30±38.05) and(195.10±50.61)s.Conclusions:Posttraumtic stress can change neuroendocrine and ethology in rats.Gegen compound can modulate theses changes.