Objective:To investigate the effects of sesamin on the hemodynamics

NO and ET-1 of myocardium in renal hypertensive rats.Methods:The two-kidney and one-clip rat model was established.Hemodynamics parameters

left ventricular weight index(LVWI)

reactive oxygen species(ROS)level

myocard nitri coxide(NO) and Endothelin-1(ET-1) concentration were measured after administration with sesamin for six weeks.The linear correlations between LVWI and NO

ET-1 were respectively analyzed.Results:Sesamin 100 mg·kg-1 group significantly decreased MAP

LVSP

LVEDP

LVWI

ROS and ET-1(P<0.01)

increased ±dp/dtmax

ACF and NO(P<0.05

P<0.01).In addition

LVWI was correlated negatively with NO(r=-0.626

P<0.01)and positively with ET-1(r=0.542

P<0.01).Conclusions:Sesamin can obviously improve the hemodynamics.These effects may relate to their antioxygen effect and effect of increasing the concentration of myocard NO and decreasing the content of myocard ET-1.