Objective: To approach preventive and therapeutic effect of Yiqihuoxuejiedu decoction on restenosis.Methods: Model of artherosclerosis restenosis in rabbits was created by stimulating arteria carotis communis with electric current

feeding rabbits with high-fat diet for 8 weeks

Doppler ultrasound estimating stegnosis of atheromatous plaque

and then broadening stenosal carotid with sacculus in home position.Model rabbits were divided into three groups randomly

consisting of model

western medicine(pravastatin plus Bamyl)

Chinese drug(Yiqihuoxuejiedu decoction).Normal and Sham operation group was negative control.Medicine containg fodder treated rabbits for 4 weeks.Blood-fat

C-reactive protein

transforming growth factor in the serum were detected respectively.HE

elasticity +VG

Masson

and immuno-histochemical α-SM-actin and macrophage RAM11 were determined.All results of pathological dyeing were gained by image analysis.Results: Yiqihuoxuejiedu decoction had outstanding effect on inhibiting collagen in hyperplasy endomembrane.It reduced an area of collagen reaching 50%(compared with model group P<0.01).Yiqihuoxuejiedu decoction also decreased the content of TGF-β and blood-fat in serum.However

Yiqihuoxuejiedu decoction had no effect on lowering content of CRP and inhibiting expression of macrophage RAM11.Conclusion:Yiqihuoxuejiedu decoction may prevent and treat restenosis after percutaneous transluminal anglography by diminishing collagen in hyperplasy endomembrane

depressing the content of blood-fat and transforming growth factor β.