肾衰颗粒对慢性肾衰竭患者血浆内皮素、一氧化氮的影响

王小娟; 雷颖; 郭建生; 郭璇; 胡芳

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肾衰颗粒对慢性肾衰竭患者血浆内皮素、一氧化氮的影响

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- 肾衰颗粒对慢性肾衰竭患者血浆内皮素、一氧化氮的影响
- The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure
- 中国实验方剂学杂志 2007年13卷第1期页码：64-66
- 作者机构：
- 作者简介：
- 基金信息：
  
  湖南省卫生厅中医药科研基金资助(202020)
- DOI：
  中图分类号：
- 纸质出版日期：2007
- 稿件说明：
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王小娟, 雷颖, 郭建生, 等. 肾衰颗粒对慢性肾衰竭患者血浆内皮素、一氧化氮的影响[J]. 中国实验方剂学杂志, 2007,13(1):64-66.

WANG Xiao-juan, LEI Ying, GUO Jian-sheng, et al. The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 64-66.
王小娟, 雷颖, 郭建生, 等. 肾衰颗粒对慢性肾衰竭患者血浆内皮素、一氧化氮的影响[J]. 中国实验方剂学杂志, 2007,13(1):64-66. DOI：

WANG Xiao-juan, LEI Ying, GUO Jian-sheng, et al. The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 64-66. DOI：

摘要

目的:观察肾衰颗粒对慢性肾功能衰竭患者的血浆内皮素(ET)、一氧化氮(NO)的影响及疗效。方法:60例慢性肾功能衰竭患者随机分为2组

治疗组30例口服肾衰颗粒

对照组30例口服包醛氧淀粉

观察2组血尿素氮(BUN)、血肌酐(SCr)、肌酐清除率(Ccr)、血浆内皮素(ET)、一氧化氮(NO)的变化。结果:治疗组BUN、Cr下降明显(P<0.01)

Ccr升高明显(P<0.01)

与阳性对照组比无差异;ET下降明显(P<0.01)

NO升高明显(P<0.01)

且均优于阳性对照组(P<0.05

P<0.01)。结论:肾衰颗粒能延缓慢性肾功能衰竭的进展。

Abstract

Objective:To observe the effect of Shen Shuai KeLi on endothelin(ET) and nitrogen monoxide(NO)of chronic renal failure(CRF).Method:60 patients with CRF were randomly divided into two groups.30 patients in treatment group were treated with ShenShuai KeLi;the other 30 patients in control group were treated with oxyamyli tectus aldehydum.The blood urea nitrogen(BUN)

serum creatinins(Scr)

ET and creatinine clearance rate(Ccr) were detected in both groups.Results:Compared with those in control group

the BUN

ET in treatment group decreased significantly(P<0.01)

and the NO

Ccr in treatment group increased significantly(P<0.01).Conclusion:ShenShuai KeLi can decrease the BUN

and Scr and increase NO and Ccr in patients with chronic renal failure

so it may delay the progress of chronic renal failure.

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