Objective:To investigate the influence of Qingzhi Capsule on mediators of inflammation and vasoactive substances in the model of LPS attack with high fat diet in mice.Methods:With high fat diet and oral qingzhi capsule for 10 days

then induced by ip.LPS at the last day.The blood was collected immediately from ophthalmovascula clump

at 2

4

6h.To measure the level of CRP

IL-6 and TNF-α.At 2h and 6h the blood of mice was collected immediately from ophthalmovascula clump

To measure the level of plasma TXB2 and 6-k-PGF1α.Results:After ip.LPS in each time point

the level of CRP

IL-6

TNF-α

TXBK2 and 6-K-PGF1α in model group have Obvious difference from the normal group;Qingzhi Capsule had strong effect on prevention of increasing TXB2 and 6-K-PGF1α

Results also indicated depressing of TXB2/6-K-PGF1α ratio in the mice.Qingzhi Capsule depressed the level of CRP at 4h and 6h in the mice with high fat diet and LPS attack

depressed the levels of IL-6 at 6h.Conclusion:Qingzhi Capsule inhibited the expression of inflammatory factors in the mice with high fat diet and LPS attack.