Objective:Study the dynamics mode of transdermal absorption of Rukang Cataplasmata and the effect of azone on transdermal absorption in order to improve the effect of Rukang Cataplasmata.Methods:Using Franz diffusion pool

with the penetration amount of Paeoniflorin in Rukang Cataplasmata at different times as the index

a Michaelis-Menten kinetics mode about transdermal absorption was obtained.Results:There were linear relationships between the penetration amount of Paeoniflorin in Rukang Cataplasmata across the mice skin and the time.Azone can improve the absorption rate and the absorbing capacity of Paeoniflorin across the mice skin.Azone at 3% was the most effective.Azone over 3%

it decrease the absorption rate and the absorbing capacity of Paeoniflorin across the mice skin.