XIAO Cheng-rong, WANG Yu-guang, DAI Fang-guo, et al. The Effect of Coadministration with on Cytochrome P450 in Rat Liver[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(12): 48-50.
XIAO Cheng-rong, WANG Yu-guang, DAI Fang-guo, et al. The Effect of Coadministration with on Cytochrome P450 in Rat Liver[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(12): 48-50.DOI:
Objective:To elucidate the imcompatible mechanism of traditional Chinese Medicine
the effect of Aconitum coadministration with Lilac Daphne on the main enzyme activity
such as CYP1A2
CYP2E1 and CYP3A1/2.Methods:CYP1A2 and CYP2E1 activities were quantitated by high performance liquid chromatographic(HPLC) assay;CYP3A1/2 activity was quantitated by UV chromatography.Results:Aconitum coadministration with Lilac Daphne obviously promoted the activities of CYP1A2
CYP2E1 and CYP3A1/2(P<0.05~0.001).Conclusion:The effect on the enzymes activity of CYP1A2、CYP2E1、CYP3A1/2 of Aconitum coadministration with Lilac Daphne may change the toxic component's metabolism and influence phamarceutical effect and toxicity.The herb-herb interaction maybe occur.