Objective:To study effects of Manjieling Capsule on ulcerative colitis.Method:The spleen insufficiency

the acute ulcerative colitis and immune ulcerative colitis models of rat were made by oral administration of Folium sennae

aoetic acid and rabbit mucous membrane of intestine protein

respectively.Result:The oral administration of Manjieling Capsule with dosage of 1.16

0.58

0.29g/kg can alleviate the pathological changes in the acute and immune ulcerative colitis and decrease the content of MDA

NO with increased activity of SOD.The decreased of TNF and IgG content

increase of IL-2 and regulation of lymphocyte subgroup proportion were found.Meanwhile

the oral administration of Manjieling Capsule with dosage of 1.16

0.58

0.29g/kg can inhibit swelling of the ears caused by xylene

reduce the blood capillary permeability of the abdominal cavity and twisting reaction with increased pain threshold value in mice.Conclusion:These results indicated that Manjieling Capsule had effects on ulcerative colitis.