KONG Xiang, YANG Jie-ren. Effects of Sesamin on Contraction of Aortic Ring,NO and ET in Renal Hypertension Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(4): 47-49.
KONG Xiang, YANG Jie-ren. Effects of Sesamin on Contraction of Aortic Ring,NO and ET in Renal Hypertension Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(4): 47-49.DOI:
Objective:To evaluate the effects of sesamin on contraction of aortic ring
NO and ET in rats with renal hypertension.Methods:Sesamin(100、33、10 mg·kg-1·d-1 was orally given in renal hypertensive rats.The responses to phenylephrine on isolated aortic rings was recorded and the levels of NO and ET were measured in aorta after six weeks of treatment.Results:100mg·kg-1 sesamin could reduce maximum contraction
increase the content of NO and decrease the level of ET(P<0.05).Conclusion:Sesamin can inhibit aortic contraction and improve vascular endothelial cell impairment.