Objective:To investigate the therapeutic mechanisms of Qing Yi decoction on acute lung injury induced by acute hemorrhagic necrotizing pancreatitis in rats.Methods:AHNP model was induced by intraductul administration of 5% sodium taurocholate in Wistar rat.Qing Yi decoction was administered orally 30 minutes after model induction.Sandostain(50μg/kg) was administrated by subcutaneous injection after model induction.The other animals were used to observe the 24hour-mortality.Animals were killed on various hours after model induction(3

6

12h).Bronchoalveolar lavage(BAL) macrophages NF-κ B activation was determined by ELISA method.Pulmonary TNFα

PLA2

myeloperoxidase(MPO)were examined.The Levels of Amylase

Lipase

PLA2 of serum were determined also.Morphologic changes of lung and pancreas were observed under light microscopy.Results:In Qing Yi decoction group

the mortality was significantly reduced;Lung and pancreas injury was markedly reduced;Qing Yi decoction significantly attenuated NF-κ B activation of BAL macrophages.PLA2

TNFα levels of serum and lung tissue were decreased significantly.Conclusions:Qing Yi decoction has protective effects on AHNP-ALI through multiple pathways

among these

the inhibitory effect on PLA2 activity is an important one.Qing Yi decoction can attenuate the "PLA2-NF-κ B-cytokine cascade" markedly.