Objective:To investigate the anxiolytic and hypnogenetic effects of Jieyuwan on animal models.Methods:The anxiolytic effects of Jieyuwan were tested in the elevated plus-maze(EPM) and stress-induced hyperthermia in singly housed mice(SIH);the hypnosis effects were studied in pentobarbital-induced sleeping time and subthreshold dose of pentobarbital test in mice.Results:Jieyuwan exhibited the anxiolytic effects in mice by increasing the time percentage into the open-arms in the elevated plus-maze and antagonize stress-induced hyperthermia in singly housed mice.Jieyuwan failed to affect the locomotor activity in mice at the test dose

suggesting Jieyuwan did not induce sedation in the anxiolytic doses.Jieyuwan could prolong the time of sleep in pentobarbital-induced sleeping time in mice and increase the percentage of falling asleep in subthreshold dose of pentobarbital test.Conclusion:Jieyuwan has definite antianxiety and hypnotic effects in animal models.