Objective:To observe therapeutic effect and mechanism of negative symptoms in schizophrenia model mice by DaWei Capsule.Methods:Negative symptoms of schizophrenia model were developed by subanesthetic-dose(30mg/kg)Ketamine-induced enhancement of immobility time of forced swimming

and shorten immobility time of forced swimming was observed.Moreover

the levels of neurotransmitter in mice brains (DA

NA

5-HT)were measured by fluorospectrophotometry in order to explore the action mechanisms.Results:Compared with model group

DaWei Capsule with large

medium

and small dose

and clozapine can significantly shorten immobility time of forced swimming in mice

and content of 5-HT in brain and serum decreased and level of NE in serum increased in DaWei Capsule group.Conclusion:DaWei capsule and clozapine have effect on the treatment of negative symptoms in schizophrenia

action mechanism of which may be involved in 5-HT and NE system in brain.