Objective:Investigate Danzhi Jiangtang Capsule's effect on peroxisome proliferator-activated receptor-γ(PPAR-γ)mRNA's expression in greater omental adipocyte in insulin resistance(IR)rats which were induced by low dose of streptozotocin(STZ)and high calorie food.Methods:Male Wistar rats were randomly divided into normal group、model group、greating group.The rats of normal group were fed with common food while the others with high calorie food and injected with low dose of STZ.Fasting plasma glucose(FPG)level and fasting insulin(FIns)level of all rats were measured by routine methods

and insulin sensitivity index(ISI)was calculated accordingly.At the end of experimental treatment

the total mRNAs of greater omental adipose tissues were extracted and the genic fragments of PPAR-γ were amplificated in order to detect their expression levels.Results:Danzhi Jiangtang Capsule could reduce the FPG level and FIns level in model rats

increase the PPAR-γ mRNA's expression and enhance ISI effectively.Conclusions:Danzhi Jiangtang Capsule can ameliorate IR conditon of the model rats and its mechanism is probably related to its effect of enhancing the genic expressional level of PPAR-γ.