Objective:To investigate Danzhi Jiangtang Capsule's effect on the GLUT4 gene expression in skeletal muscle of diabetic IR rat and to find out its functional target.Methods:Male Wistar rats were randomly divided into six groups(normal group

model group

Rosiglitazone Maleate Tablets treating group

Rosiglitazone Maleate Tablets and high dose of Danzhi Jiangtang Capsule treating group

low dose of Danzhi Jiangtang Capsule treating group

high dose of Danzhi Jiangtang Capsule treating group).The rats of normal group were fed with common food while the others with high calorie food and injected with low dose of STZ.The body weigh

fasting blood glucose(FBG)

fasting insulin(FIns)

blood fat of all rats were measured.Insulin sensitivity index(ISI) was calculated accordingly

and the expression of GLUT4 gene in skeletal muscle of diabetic IR rat was also measured.Results:Danzhi Jiangtang Capsule could reduce body weight

FBG level and FIns level

and improve blood fat condition.Danzhi Jiangtang Capsule could increase the expression of GLUT4 gene in skeletai muscle of diabetic IR rat

thereby it improved insulin sensitivity of peripheral tissue.Conclusions:Danzhi Jiangtang Capsule can ameliorate diabetic IR condition of the model rats and its mechanism is probably related to its effect of enhancing the genic expressional level of GLUT4.