Objective:To investigate the antitussive

expectorant and antiasthmatic effects and antiasthmatic mechanism of Kechuanping granules.Methods:Ammonia-induced cough in mouse and chloric acetylcholine-induced asthma in guinea pig were used.Effects of Kechuanping granules on phenol red displacement in mouse and phlegm secretion in rat were observed.The leukotrienes content in lung tissue and bronchoalveolar lavage fluid of ovalbumin(OVA) -induced asthma mouse were determined.Results:Kechuanping granules could inhibit ammonia-induced cough in mouse and chloric acetylcholine-induced asthma in guinea pig.Kechuanping granules also increased phenol red displacement in mouse and phlegm secretion in rat.Furthermore

Kechuanping granules could inhibit the LTB4 content in lung tissue and cysLTs content in BAL fluid of OVA-challenged mouse.Conclusions: Kechuanping granules have antitussive

expectorant and antiasthmatic effects.The mechanism by which Kechuanping granules inhibited the asthma in ovalbumin-induced mouse might partialy be via arachidonic acid metabolic way.