胃滞留漂浮型缓控释制剂的研究概况

曲莉1; 2; 王智民1; 仝燕1

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胃滞留漂浮型缓控释制剂的研究概况

更新时间：2024-01-04

- 胃滞留漂浮型缓控释制剂的研究概况
- Advance on Controlled-and Sustained-release Dosage Forms Remaining Floating in Stomach with Prolonged Gastric Resident Time
- 中国实验方剂学杂志 2006年12卷第7期页码：66-70
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- 纸质出版日期：2006
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曲莉1, 2, 王智民1, 等. 胃滞留漂浮型缓控释制剂的研究概况[J]. 中国实验方剂学杂志, 2006,12(7):66-70.

QU Li1, 2, WANG Zhi-min1, et al. Advance on Controlled-and Sustained-release Dosage Forms Remaining Floating in Stomach with Prolonged Gastric Resident Time[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(7): 66-70.
曲莉1, 2, 王智民1, 等. 胃滞留漂浮型缓控释制剂的研究概况[J]. 中国实验方剂学杂志, 2006,12(7):66-70. DOI：

QU Li1, 2, WANG Zhi-min1, et al. Advance on Controlled-and Sustained-release Dosage Forms Remaining Floating in Stomach with Prolonged Gastric Resident Time[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(7): 66-70. DOI：

摘要

综述了胃滞留漂浮型缓控释给药系统的释药原理、漂浮性能的影响因素及制剂质量评价等方面的内容。根据近十年来国内外文献报道介绍胃滞留漂浮型缓控释制剂的研究进展情况

阐述了制剂主要适用于在胃部或者小肠上部有特定吸收或具有专属性治疗等药物

通过延长药物在胃肠道内的滞留时间来提高药物的生物利用度和有效性;因此该制剂具有广阔的发展前景。

Abstract

This paper reviews the theory of releasing drugs on floating sustained-release dosage forms for gastric retention and influential factors of floating and evaluation on dosage quality control.According to the development on the dosage forms in recent decades

such retention systems are important for drugs that are best for absorption in the stomach or upper the intestine as well as for controlling release of the drugs having site-specific absorption limitations.Retention of drug delivery system in stomach prolongs overall gastrointestinal transit time

thereby resulting in improved bioavailability and efficiency for some drugs.

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