综合评分法优化银杏叶分散片处方

胡容峰1; 2; 朱家壁1; 彭代银2; 汤继辉2

您当前的位置：

首页 >

文章列表页 >

综合评分法优化银杏叶分散片处方

更新时间：2024-01-04

- 综合评分法优化银杏叶分散片处方
- Optimization of Formulation of Ginkgobiloba Immediate Release Tablet
- 中国实验方剂学杂志 2006年12卷第2期页码：7-10
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2006
- 稿件说明：
移动端阅览
胡容峰1, 2, 朱家壁1, 等. 综合评分法优化银杏叶分散片处方[J]. 中国实验方剂学杂志, 2006,12(2):7-10.

HU Rong-feng1, 2, ZHU Jia-bi1, et al. Optimization of Formulation of Ginkgobiloba Immediate Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(2): 7-10.
胡容峰1, 2, 朱家壁1, 等. 综合评分法优化银杏叶分散片处方[J]. 中国实验方剂学杂志, 2006,12(2):7-10. DOI：

HU Rong-feng1, 2, ZHU Jia-bi1, et al. Optimization of Formulation of Ginkgobiloba Immediate Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(2): 7-10. DOI：

摘要

目的:优化银杏叶分散片处方

制备中药口服固体速释制剂。方法:以颗粒的流动性、片剂的崩解时间、片剂的硬度和片剂中有效成分的溶出速度为指标

采用正交设计综合评分法优化干法制粒制备银杏叶分散片的处方和制备工艺。结果:优化所得处方为微晶纤维素40%

羧甲基淀粉钠10%

糊精约15%。以此处方制备的银杏叶分散片在崩解时间不超过3min

硬度为4.9KG

有效成分的溶出速度参数T50为3.4min。结论:优化所得处方合理稳定

银杏叶分散片具有明显的速释特征。

Abstract

Objective:To optimize the formulation of the Ginkgobiloba immediate release tablet.Method:The immediate release tablet was prepared by using dry granules.The formulation and preparation technology was optimized by using orthogonal design which took the flow property of granules

the hardness

the disintegrating time and the dissolution rate of the tablet as indices.Result:The optimized formulation contained 40% microcrystalline cellulose

10% sodium carboxymethyl starch and 15% dextrin.The hardness

the disintegrating time and T50 of the tablet were 4.9KG

3min and 3.4min respectively.Conclusion: It is successful to prepare immediate release tablet.The optimized formulation is rational and stable

the tablet could be released quickly.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据