月华胶囊对耐多药结核鼠T淋巴细胞亚群及细胞因子的影响

欧阳建军1; 伍参荣1; 陈北阳1; 白宇乾2; 曾姣飞1

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月华胶囊对耐多药结核鼠T淋巴细胞亚群及细胞因子的影响

更新时间：2024-01-04

- 月华胶囊对耐多药结核鼠T淋巴细胞亚群及细胞因子的影响
- The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)
- 中国实验方剂学杂志 2006年12卷第9期页码：28-30
- 作者机构：
- 作者简介：
- 基金信息：
  
  湖南省自然科学基金资助项目(03JJY3041)
- DOI：
  中图分类号：
- 纸质出版日期：2006
- 稿件说明：
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欧阳建军1, 伍参荣1, 陈北阳1, 等. 月华胶囊对耐多药结核鼠T淋巴细胞亚群及细胞因子的影响[J]. 中国实验方剂学杂志, 2006,12(9):28-30.

OUYANG Jian-jun 1, WU Can-rong1, CHEN Bei-yang1, et al. The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(9): 28-30.
欧阳建军1, 伍参荣1, 陈北阳1, 等. 月华胶囊对耐多药结核鼠T淋巴细胞亚群及细胞因子的影响[J]. 中国实验方剂学杂志, 2006,12(9):28-30. DOI：

OUYANG Jian-jun 1, WU Can-rong1, CHEN Bei-yang1, et al. The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(9): 28-30. DOI：

摘要

目的:观察月华胶囊对耐多药结核鼠T淋巴细胞亚群、TH1/TH2细胞因子的影响及其机理。方法:将耐多药结核鼠随机分成模型组、月华胶囊组、抗结核药(OEZD)组、月华胶囊+抗结核药组

另设正常组。测各组中的CD4、CD8、CD4/CD8、IFN-γ、IL-2、IL-10、TNF-α。结果:①与模型组比较

月华胶囊组、抗结核药组、月华胶囊+抗结核药组均明显减少CD4、CD4/CD8、INF-γ、IL-2降低(P<0.01)

明显改善IL-10、INF-α升高(P<0.05);②与抗结核药组比较

月华胶囊+抗结核药组各指标差异均有显著性(P<0.05)。结论:月华胶囊对耐多药结核鼠有治疗作用

其机理是通过调控T淋巴细胞亚群CD4、CD4/CD8及其TH1型细胞因子IFN-γ、IL-2

TH2型细胞因子IL-10和TNF-α的水平而实现的。

Abstract

Objective:To observe the possible influence of YUEHUA capsule(YHC) on T Lymphocyte subgroup and TH1/TH2 cytokines in rats with Multi-drug resistant tuberculosis (MDR-TB) and its mechanism for this effect.Methods:The experimental rats

as the studying model

were Divided into the modeling group

YHC group

the drug of antituberculosis (OEZD) group and YHC & OEZD group in random process. And there was normal group. Then CD4+

CD8+

CD4+/CD8+

IFN-γ

IL-2

IL-10

and TNF-α were observed in the all group.Result:Compared with the modeling group

CD4+

CD4+/CD8+

IFN-γ and IL-2 were significantly controlled to go down(P<0.01)

and IL-10

INF-α were significantly controlled to go up (P<0.05) in YHC group

OEZD group and YHC & OEZD group. Compared with OEZD group

in YHC & OEZD group the findings were significantly different(P<0.05).Conclusion:YHC holds therapeutic effects on rats with MDR-TB. These effects may be associated with the controlled Level of CD4+

CD4+/CD8+ and TH1/TH2 cytokines

including IFN-γ

IL-2 and IL-10

and TNF-α.

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