低5-羟色胺状态介导的NO超敏实验及大川芎丸的干预作用

杨洪军; 李耿; 边宝林

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低5-羟色胺状态介导的NO超敏实验及大川芎丸的干预作用

更新时间：2024-01-04

- 低5-羟色胺状态介导的NO超敏实验及大川芎丸的干预作用
- Nitric Oxide Supersensitivity induced by hyposerotonin and the Pharmacological Effect of Dachuanxiong Pill
- 中国实验方剂学杂志 2005年11卷第1期页码：28-30
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- 纸质出版日期：2005
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杨洪军, 李耿, 边宝林. 低5-羟色胺状态介导的NO超敏实验及大川芎丸的干预作用[J]. 中国实验方剂学杂志, 2005,11(1):28-30.

YANG Hong-jun, LI Geng, BIAN Bao-lin. Nitric Oxide Supersensitivity induced by hyposerotonin and the Pharmacological Effect of Dachuanxiong Pill[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(1): 28-30.
杨洪军, 李耿, 边宝林. 低5-羟色胺状态介导的NO超敏实验及大川芎丸的干预作用[J]. 中国实验方剂学杂志, 2005,11(1):28-30. DOI：

YANG Hong-jun, LI Geng, BIAN Bao-lin. Nitric Oxide Supersensitivity induced by hyposerotonin and the Pharmacological Effect of Dachuanxiong Pill[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(1): 28-30. DOI：

摘要

目的:观察低5-羟色胺(5-HT)状态下脑血管对一氧化氮(NO)的敏感性增高现象

及大川芎丸的干预作用。方法:运用微循环技术观察软脑膜血管管径。腹腔注射对氯苯丙胺酸(PCPA)造成低5-HT状态

以观察脑血管对NO的超敏现象；连续灌胃大川芎丸7d后

以观察该药对正常状态和低5HT状态扩张血管的干预作用。结果:低5-HT状态下

NO扩张脑血管的作用明显强于正常状态。大川芎丸可以抑制低5-HT状态下NO导致的脑血管的过度扩张。结论:低5-HT状态下

脑血管对NO的反应性增强；大川芎丸可以抑制脑血管的过度扩张

可能是其治疗偏头痛的作用机制之一。

Abstract

Objective:To observe the enhanced sensitivity of the cerebral vascular NO under hyposerotonin and the pharmacological effect of Dachuanxiong Pill.Method:the diameter of paiamatral vascular was observed using microcircular technique;The hyperserotonin was establishal by intraperitoneal injection of PCPA in rats;Intervention of Dachuanxiong Pill in vascular oliation induced by NO under normal and hyposerotonin state was inverstigaterol after intragastric administration of Dachuanxion Pill for seven days.Result:The vascular dilation induced by NO under hyposerotonin is more obvious than in normal state.Dachuanxiong Pill showed antagonism to excessive vasodilatation induced by No under hyposerotonin.Conclusion:Hyposerotonin has significan enhance of cerebral vascular to No;Dachuanxiong Pill an inhibition of the cerebral vascular dilation

which may one of for trentment of migraine indicated.

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