三七复合有效成分对恒河猴细菌感染性子宫出血模型内膜组织一氧化氮及一氧化氮合酶的影响

尤昭玲1; 马红霞2; 王若光1; 谈诊如1; 林洁1; 余建1

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三七复合有效成分对恒河猴细菌感染性子宫出血模型内膜组织一氧化氮及一氧化氮合酶的影响

更新时间：2024-01-04

- 三七复合有效成分对恒河猴细菌感染性子宫出血模型内膜组织一氧化氮及一氧化氮合酶的影响
- Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of
- 中国实验方剂学杂志 2004年10卷第5期页码：18-20
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金(30271633);湖南省社会发展重大项目(01SSY1002-4)
- DOI：
  中图分类号：
- 纸质出版日期：2004
- 稿件说明：
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尤昭玲1, 马红霞2, 王若光1, 等. 三七复合有效成分对恒河猴细菌感染性子宫出血模型内膜组织一氧化氮及一氧化氮合酶的影响[J]. 中国实验方剂学杂志, 2004,10(5):18-20.

YOU Zhao-ling1, MA Hong-xia2, WANG Ruo-guang1, et al. Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of [J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 18-20.
尤昭玲1, 马红霞2, 王若光1, 等. 三七复合有效成分对恒河猴细菌感染性子宫出血模型内膜组织一氧化氮及一氧化氮合酶的影响[J]. 中国实验方剂学杂志, 2004,10(5):18-20. DOI：

YOU Zhao-ling1, MA Hong-xia2, WANG Ruo-guang1, et al. Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of [J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 18-20. DOI：

摘要

目的:探讨一氧化氮(NO)及诱导型一氧化氮合酶(iNOS)在炎性子宫出血中的作用及三七复合有效成分的影响。方法:选择月经正常雌性育龄恒河猴11只

随机分为中药组(三七复合有效成分)4只、模型组4只及正常对照组3只。应用化学比色法检测三组子宫内膜中一氧化氮及一氧化氮合酶的活性

用免疫组化法检测三组子宫内膜中一氧化氮合酶(iNOS)蛋白的表达水平。结果:中药组与模型组比较

子宫内膜NO、iNOS的活性及iNOS蛋白表达水平明显降低

差异有显著性

P0.01;结论:NO可能参与了炎性子宫出血的发病机制

三七减少炎性子宫出血的机制可能与调节NO、iNOS的活性及iNOS蛋白表达水平有关。

Abstract

Objective:To explore the influence of two kinds of active components from Panax notoginseng on NO and iNOS on inflammatory Metrorrhagia model of Macaca multatta. Methods:Eleven normal menorrhea adult Rhesus monkeys were choosed as research object

and were divided into model group (four)

TCM group(four) and Control group(three) at random.Colorimetric method were performed to estimate the activity of NO and iNOS in of model group

TCM group and normal control group

the immunohistochemical S-p were performed to estimate the express level of iNOS in the endometrium of the three groups.Result:Compared to the model group

the activity of No and iNOS and the express level of iNOS in the endometrium of TCM gorup was obviously weaker

which are similar to that of the normal group.Conclusion:NO may be involred in the pathogenesis of inflammatory Metrorrhagia.Two kinds of active components from Panax notoginseng reduce inflammatory Metrorrhagia by regulating the activities of NO and iNOS and the express level of iNOS in the endometrium.

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