Purpose:To explore the mechanism of Shenfu Injection in treating cancer cachexia (C.C.) Method:mRNA was extracted from the blood cells and tumor tissue of T739 animal model of C.C.

hybridizated respectively on 20S gene chip.Analysis on differential expression genes was carried out.Result:56 differential expression genes were obtained from each chip of blood cell and tumor tissue

57.1% and 55.4% of which belongs to mouse musculus cDNA library. 9 cross-genes were obtained from each chip of blood cell and tumor tissue

showing the same tendency of up-regulation or down-regulation. 4 of them belongs to mouse musculus cDNA library.Disscussion:1.The result suggests The gene segment of mouse musulus cDNA library might cause over-consumption of muscular tissue and results in C.C.; 2.Previous studies confirmed that inflammatory cytokines

such as IL-1 and IL-6 are closely related to C.C. Gene expression of ADAMTS-1 is correlated with inflammatory proceeding.The result showed that ADAMTS-1 of cross-genes showed a tendency of up-regulation

which is worth further studying; 3.The gene SCD2 showed a tendency of up-regulation. It was inferred that its expression was correlated with metabolism and function of adipose tissue

which further affected malnutrition in C.C. stage; 4.Described as progesterone receptor-associated immunophilin

FKBP51 displays interactions with progesterone receptor.The gene showed the same tendency as the gene chip study of medroxyprogesterone anti-C.C. at the same stage. As medroxyprogesterone was a confirmed effective drug for C.C.

FKBP51 was deduced to have the same function as medroxyprogesterone. 5.PTA is the member of thymosin family and has immune regulatory effect.The gene expression showed a tendency of up-regulation after Shenfu Injection treatment.Shenfu Injection was thought to stimulate T cell immunity and further improve symptoms through elevating immune ability.