Aim:To study effect of the tablet extracted from rhubarb on hyperinsulinmia in simple obese rats.Methods:The simple obese rats with hyperinsulinmia were randomly divided into two groups:experimental group was composed of eight rats

administrated with tablet extracted from rhubarb

0.25g/100gb.w/day

control group:eight rats

administrated with N.S.The serum insulin and peptide C were detected by radioimmunoassay

the serum TNF-α by ELISA.Results:After administration of tablet extracted from rhubarb for one month

the body weight in experimental rats was obviously reduced

at the same time

the level of insulin

peptide C and TNF-α remarkably lowered.There is a positive relationship between the serum insulin and TNF-αlevel.Conclusion:The tablet extracted from rhubarb demonstrated significant effects on reducing body weight and lowering the serum insulin level in hyperinsulinmia in simple obese rats

which may be contributed to the decrease of TNF-α level