HAN Xiao1, LIU Wen2, QIU De-wen2, et al. Study on Analgesic Effect of Duliang Pill(DLP) Extract and Its Effect on C-fos Gene Expression of Periphery Tissue[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(4): 34-36.
HAN Xiao1, LIU Wen2, QIU De-wen2, et al. Study on Analgesic Effect of Duliang Pill(DLP) Extract and Its Effect on C-fos Gene Expression of Periphery Tissue[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(4): 34-36.DOI:
Objective:To study the analgesic mechanism of DLP extract on FCA-induced pain model. Methods:Experiment detected the pain threshold
pain grade and the expression of c-fos gene in periphery tissue by using the methods of immunohistochemistry. Results DLP extract showed obvious effects
compared with model group (P<0.05)
on enhancing the pain threshold and restraining the Fos expression of periphery tissue. Conclusion:DLP extract has analgesic effect and its analgesic effect was probably associated with its effect on restraining the Fos expression of periphery tissue.