桂枝汤对发热及低体温大鼠下丘脑15-羟基前列腺素脱氢酶活性的影响

李沧海; 霍海如; 周军; 郭淑英; 姜廷良

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桂枝汤对发热及低体温大鼠下丘脑15-羟基前列腺素脱氢酶活性的影响

更新时间：2024-01-04

- 桂枝汤对发热及低体温大鼠下丘脑15-羟基前列腺素脱氢酶活性的影响
- Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang
- 中国实验方剂学杂志 2003年9卷第1期页码：27-30
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家“九五”攀登计划预选项目(中药现代化关键问题的基础研究)(970211018)
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  中图分类号：
- 纸质出版日期：2003
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李沧海, 霍海如, 周军, 等. 桂枝汤对发热及低体温大鼠下丘脑15-羟基前列腺素脱氢酶活性的影响[J]. 中国实验方剂学杂志, 2003,9(1):27-30.

LI Cang-hai, Huo Hai-ru, Zhou Jun, et al. Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(1): 27-30.
李沧海, 霍海如, 周军, 等. 桂枝汤对发热及低体温大鼠下丘脑15-羟基前列腺素脱氢酶活性的影响[J]. 中国实验方剂学杂志, 2003,9(1):27-30. DOI：

LI Cang-hai, Huo Hai-ru, Zhou Jun, et al. Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(1): 27-30. DOI：

摘要

目的:研究桂枝汤对发热和低体温大鼠下丘脑组织内15-PGDH活性的影响

进一步阐明桂枝汤体温双向调节作用机制。方法:采用核素示踪技术测定酵母性发热和安痛定性低体温大鼠及桂枝汤处理组下丘脑组织内15-PGDH活性

并观察其与体温变化的关系。结果:皮下注射酵母可降低下丘脑15-PGDH活性

桂枝汤灌胃可剂量依赖性地抑制该变化并促进发热大鼠体温的恢复

两者呈正相关;而腹腔注射安痛定后

随着体温下降

15-PGDH活性有升高倾向

桂枝汤可抑制该酶活性并加速体温恢复正常

但两者呈弱相关。结论:大鼠下丘脑内15-PGDH可能参与机体体温调节并可能是桂枝汤解热作用靶点之一

但与其抗低体温作用关联不大。

Abstract

To further highlight Guizhi Tang's mechanism of dual-directional thermoregulation

the 15-PGDH activity in pyretic and hypothermia rats was detected using isotopic tracing assay.A decrease in PGDH activity paralleled with a pronounced rise in body temperature in rat hypothalamus 5.5hr after a s.c. yeast-injection was observed and both the responses was counteracted by the treatment of Guizhi Tang orally in a dose-dependent manner.Aminopyrine induced a tendency to enhance PGDH activity and a marked drop in body temperature meanwhile in rats 1 hr later

but there was a poor relation between changes in body temperature and in activity of PGDH evoked by Guizhi Tang.Present data suggest that PGDH in hypothalamus may play a role in thermoregulation in rats and is also a target of antipyretic action of Guizhi Tang

but it probably does not contribute to anti-hypothermia action of Guizhi Tang.

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