Objective:To explore the pharmacological effect of Qianhu Ketan Tang(QKT).Methods:Mouse model of cough and model of asthma were established by using ammonia and histamine with acetycholine inspiration accordingly. We investigated effects of OKT and a positive drug on expectorant by using the model with intraperitoneal injection of phenolsulfonphthalein. The anti-virus action of QKT was evaluated by a model of virus infection induced by influenzavirus nosedrop.Results:1 QKT high dose group and QKT low dose group can prolong the cough incubation period in mice. 2 QKT high dose group can increase the excretion of phenolsulfonphthalein. 3 QKT high dose group can prolong the sathma incubation period in mice. 4 The lung weights of QKT high dose group are lower than that of model group. Conclusion:QKT have good effect of cough suppression

expectorant and relieving asthma

and it can protect lung from attack of virus.