参麦注射液对内皮细胞增殖和迁移的影响

丁志山; 高承贤; 尹丽慧; 陈铌铍; 沃兴德

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参麦注射液对内皮细胞增殖和迁移的影响

更新时间：2024-01-04

- 参麦注射液对内皮细胞增殖和迁移的影响
- An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration
- 中国实验方剂学杂志 2003年9卷第2期页码：30-32
- 作者机构：
- 作者简介：
- 基金信息：
  
  浙江省自然科学基金(No.399009);浙江省中医管理局科研基金(No.2000C11)资助项目
- DOI：
  中图分类号：
- 纸质出版日期：2003
- 稿件说明：
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丁志山, 高承贤, 尹丽慧, 等. 参麦注射液对内皮细胞增殖和迁移的影响[J]. 中国实验方剂学杂志, 2003,9(2):30-32.

DING-Zhi-san, GAO Cheng-xian, YIN Li-hui, et al. An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(2): 30-32.
丁志山, 高承贤, 尹丽慧, 等. 参麦注射液对内皮细胞增殖和迁移的影响[J]. 中国实验方剂学杂志, 2003,9(2):30-32. DOI：

DING-Zhi-san, GAO Cheng-xian, YIN Li-hui, et al. An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(2): 30-32. DOI：

摘要

目的:探讨参麦注射液对血管生成的影响

方法:采用MTT法检测参麦注射液对牛血清和肿瘤细胞条件培养液促进的牛主动脉内皮细胞增殖的影响

采用琼脂糖刮除法检测参麦对牛血清和肿瘤条件培养液促进的牛内皮细胞迁移的影响。结果:在含10%新生小牛血清培养液中和在肿瘤细胞条件培养液中

参麦都能明显抑制牛主动脉内皮细胞增殖

且呈量效关系

对肿瘤细胞条件培养液诱导的内皮细胞迁移抑制作用显著。结论:参麦能抑制牛内皮细胞增殖和迁移

具有抑制血管生成的作用。

Abstract

Object:To study the effects of Shenmai injection on angiogenesis. Methods:Proliferation of bovine aortic endothelial cells(BAECs) were measured by MTT colorimetric assay after treated by various concentrations of Shenmai injection. The effects of Shenmai injection on proliferation of BAECs induced by conditioned medium of tumor(CM) were also measured by the same method. The effect of various concentrations of Shenmai on the migration of BAECs induced by fetal bovine serurm(FBS) or CM was investigated by agarose assay. Results:Shenmai injection significanly inhibited proliferation of BAECs induced by FBS or CM. And Shenmai injection inhibited the proliferation of BAECs in a dose-dependent manner. Shenmai injection inhibited migration of BAECs induced by FBS or CM. Conclusion:Shenmai injection can inhibit proliferation and migraion of bovine aortic endothelial cells. It is suggested that Shenmai can suppress angiogenesis.

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