Objective:To evaluate the curable effect of Zhinao capsule in treatment of vascular dementia (VaD). Methods: 90 cases of VaD were divided randomly into two groups with single-blind method

60 cases were administered with Zhinao capsule as treatment group

30 cases were treated with Hydergine orally as control group. Results: The total effective rate in the treatment group were 63.3%

whereas in the control group were 53.3%. The differences between two groups were not significant. On the other hand

the effect of the treatment group in improving indexes of TCM syndromes and hemorrheology was superior to the control group. In the meantime

the treatment group could increase the scores of minin-mental state examination (MMSE) and Hasegawa's dementia scale-revision (HDS-R)

reduce the scores of activities of daily living (ADL) and neural functional defect

and improve cerebral blood-flow and abnormal electroencephalograph

There were not significant differences between the two groups. Conclusion: Zhinao capsule exerts a certain effect on VaD.