泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响

杨新波; 黄正明; 曹文斌; 陈鸿艳; 田文辉; 王建华

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泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响

更新时间：2024-01-04

- 泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响
- Effect of Extract from on Normal and Alloxan Model in Mice
- 中国实验方剂学杂志 2002年8卷第3期页码：24-25
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- 纸质出版日期：2002
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杨新波, 黄正明, 曹文斌, 等. 泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响[J]. 中国实验方剂学杂志, 2002,8(3):24-25.

YANG Xin-bo, HUANG Zheng-ming, CAO Wen-bin, et al. Effect of Extract from on Normal and Alloxan Model in Mice[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 24-25.
杨新波, 黄正明, 曹文斌, 等. 泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响[J]. 中国实验方剂学杂志, 2002,8(3):24-25. DOI：

YANG Xin-bo, HUANG Zheng-ming, CAO Wen-bin, et al. Effect of Extract from on Normal and Alloxan Model in Mice[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 24-25. DOI：

摘要

目的:研究泽泻水提醇沉法提取物(RAE)的抗糖尿病作用。方法:给小鼠尾静脉注射四氧嘧啶90mg·kg-1

造成糖尿病模型。测定血糖(Glu)、甘油三酯(Trig)、胆固醇(Chol)、胰淀粉酶(Amy)和血清胰岛素(Ins)。光镜下观察胰腺和胰岛的组织学变化。结果:RAE可使正常小鼠血糖明显降低。治疗7天可使四氧嘧啶小鼠Glu和Trig降低。光镜下观察RAE治疗后的四氧嘧啶小鼠

胰岛保持正常组织学形态。RAE还可升高血清Ins水平及对抗四氧嘧啶诱发的Amy降低。

Abstract

Mice were injected with alloxan

90mg/kg

introcaudal veins

to induce diabetes.Blood glucose(Glu)

triglyceride(Trig)

cholesterol(Chol)and pancreatic amylase(Amy)were determined by using Automatic Biochemistry Analysor

and serum insulin(Ins) was determined by radioimmunoassay

the pathological examinations of pancreas and islets wee observed under light microscope.Results showed:RAE

3.0g/kg ig

reduced the bolld glucose in normal mice after a single administration.RAE(1.5

3.0g/kg ig)also decreased Glu and Trig after administration for 7 days in alloxan-induced hyperglycemic mice.Pathological examination manifested approximate normal pathology distinction in RAE-treated group.RAE also increased the release of INS

and was able to arise the lowered Amy in diabetic mice.

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