补阳还五汤和有效部位组方对沙土鼠脑缺血及再灌注后脑组织EAA的影响

邓常青1; 邓奕晖1; 贺福元1; 唐映红2

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补阳还五汤和有效部位组方对沙土鼠脑缺血及再灌注后脑组织EAA的影响

更新时间：2024-01-04

- 补阳还五汤和有效部位组方对沙土鼠脑缺血及再灌注后脑组织EAA的影响
- Effects of Bu Yang Huan Wu Decoction and its Active Fraction on Excitatory Amino Acid of Brain Tissue After Cerebral Ischemia and Reperfusion in Gerbils
- 中国实验方剂学杂志 2001年7卷第6期页码：24-27
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金No:39770893
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  中图分类号：
- 纸质出版日期：2001
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邓常青1, 邓奕晖1, 贺福元1, 等. 补阳还五汤和有效部位组方对沙土鼠脑缺血及再灌注后脑组织EAA的影响[J]. 中国实验方剂学杂志, 2001,7(6):24-27.

DENG Chang-qing1, DENG Yi-hui1, HE Fu-yang1, et al. Effects of Bu Yang Huan Wu Decoction and its Active Fraction on Excitatory Amino Acid of Brain Tissue After Cerebral Ischemia and Reperfusion in Gerbils[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(6): 24-27.
邓常青1, 邓奕晖1, 贺福元1, 等. 补阳还五汤和有效部位组方对沙土鼠脑缺血及再灌注后脑组织EAA的影响[J]. 中国实验方剂学杂志, 2001,7(6):24-27. DOI：

DENG Chang-qing1, DENG Yi-hui1, HE Fu-yang1, et al. Effects of Bu Yang Huan Wu Decoction and its Active Fraction on Excitatory Amino Acid of Brain Tissue After Cerebral Ischemia and Reperfusion in Gerbils[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(6): 24-27. DOI：

摘要

目的:比较研究补阳还五汤和其有效部位组方抗脑缺血及其再灌注损伤与脑组织兴奋性氨基酸(EAA)的关系。方法:采用沙土鼠双侧颈总动脉夹闭脑缺血模型

于缺血15min和再灌注48h取脑组织测定Glu、Asp、GABA和Gly。结果:①缺血15min后

脑组织Glu和Asp含量明显升高

GABA含量升高

补阳还五汤可使脑组织Glu含量降低

有效部位组方可使脑组织Glu和Asp含量均降低(P<0.05)。②缺血15min再灌注48h后

脑组织Glu和Asp含量均显著升高(P<0.05)

补阳还五汤可使脑组织Glu含量降低

而有效部位组方可使脑组织Glu和Asp含量均降低(P<0.05)。结论:兴奋性氨基酸的兴奋毒性参与了脑缺血及其再灌注后的脑损伤

补阳还五汤和其有效部位组方抗缺血性脑损伤的作用机理可能与其对抗脑缺血及其再灌注后EAA的升高有关。

Abstract

To compare the effects of Bu Yang Huan Wu Deciction (BYHWD) and its active fraction on brain tissue following cerebral ischemia and reperfusion

Ceredral ischemia model in gerbils was indcued by ligating bilateral common carotid artery.The contents of glutamate (Glu)

aspirate (Asp) and γ-amino butyric acid

glycine in brain tissue were determined after cerebral ischemia for 15min followed by reperfusion for 48 hours.Results showed the contents of Glu

Asp and γ-aminobutyric acid in brain tissue were markedly enhanced after cerebral ischemia for 15min.BYHWD decreased the contents of Glu in brain tissue remarkably;its active fraction reduced the contents of both Glu and Asp in brain tissue remarkably.The contents of Glu and Asp in brain tissue were remarkably increased after cerebral ischemia for 15min followed by reperfusion for 48 hours

BYHWD decreased the contents of Glu in brain tissue significantly

its active fraction reduced the contents of both Glu and Asp in brain tissue remarkably.

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