To study the protective effect and the possible mechanism of Pian Tan Fu Kang Capsule (PTFK) on injury induced by cerebral ischemia and reperfusion in rats

Rats were exposed to right middle cerebral artery occlusion for 40 min and reperfusion for 24 hours. Pathological changes

content of water on brain tissue

content changes of endothelin (ET) and calcitonin gene related peptide (CGRP) on plasma

and content changes of superoxide dismutase (SOD) and nitric oxide (NO) in serum were observed. Results showed PTFK could significantly alleviate the pathological damage and reduce content of water on brain tissue compared with injury side of brain

it could obviously increase contents of SOD in serum and CGRP on plasma

and decrease contents of NO in serum and ET in serum and ET in plasma compared with control group. The results indicate the protective effect of PTFK on cerebral ischemia and reperfusion injury might be relation to regulating balances of ET

CGRP

SOD and NO in plasma or serum.