4味中药对体外培养成骨样细胞增殖的影响——对通补强骨方中主要组成药物的研究

秦腊梅1; 肖永华1; 周丽珍2; 郝瑞福2; 牛福玲1; 姜良铎1

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4味中药对体外培养成骨样细胞增殖的影响——对通补强骨方中主要组成药物的研究

更新时间：2024-01-04

- 4味中药对体外培养成骨样细胞增殖的影响——对通补强骨方中主要组成药物的研究
- The Influence of Four Single Herbs on Proliferation of Osteoblast-like Cells in : Study on the Components of Chinese Formula-Tong Bu Qiang Gu Fang.
- 中国实验方剂学杂志 2002年8卷第2期页码：18-20
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- 纸质出版日期：2002
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秦腊梅1, 肖永华1, 周丽珍2, 等. 4味中药对体外培养成骨样细胞增殖的影响——对通补强骨方中主要组成药物的研究[J]. 中国实验方剂学杂志, 2002,8(2):18-20.

QIN La-mei1, XIAO Yong-hua1, ZOU Li-zhen2, et al. The Influence of Four Single Herbs on Proliferation of Osteoblast-like Cells in : Study on the Components of Chinese Formula-Tong Bu Qiang Gu Fang.[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(2): 18-20.
秦腊梅1, 肖永华1, 周丽珍2, 等. 4味中药对体外培养成骨样细胞增殖的影响——对通补强骨方中主要组成药物的研究[J]. 中国实验方剂学杂志, 2002,8(2):18-20. DOI：

QIN La-mei1, XIAO Yong-hua1, ZOU Li-zhen2, et al. The Influence of Four Single Herbs on Proliferation of Osteoblast-like Cells in : Study on the Components of Chinese Formula-Tong Bu Qiang Gu Fang.[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(2): 18-20. DOI：

摘要

应用UMR-106成骨细胞株

观察通补强骨方中的四味主要药物淫羊藿、女贞子、黄芪、大黄对成骨细胞株增殖情况的影响。结果发现:四种药物在适当浓度均能促进成骨细胞增殖。其中黄芪在低浓度(5mg/L)即显示促增殖作用

其作用强度与剂量无明显联系;淫羊藿、女贞子高浓度组(500mg/L)较低浓度组(5mg/L)促增殖作用有上升趋势;大黄中浓度(100mg/L)有促增殖作用

高浓度(1000mg/L)有抑制成骨细胞增殖作用。

Abstract

It has been shown that Tong Bu Qiang Gu Fang (TBQGF) has a good effect on the treatment of osteoporosis. Using the cell strain UMR 106

we observed the effects of several Chinese herbs

which were most important in the composition of TBQGF

on the proliferation of osteoblast-like cells in- vitro.- And we found that all of the Chinese herbs at appropriate concentrations could significantly promote the proliferation of osteoblasts. The high concentrations (500mg/L) of the Epimedii Hb and Ligustri Lucidi Fr had stronger effects on the proliferation of osteoblast-like cells than the low concentration (5mg/L). Astragali Membranace Rx showed a good effect at low concentration (5mg/L)

but no dose dependence relationship. Radix et Rhizoma of low concentration had no effect at all

the medium concentration (100mg/L) of it showed a significant promoting-proliferation effect

while the high concentration (1000mg/L) inhibited the proliferation of the cells. The results suggested that the herbs could promote the proliferation of osteoblast-like cells.

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