理气止疼与活血止疼治则镇痛作用的比较药理学研究(Ⅰ)——失笑散与金铃子散镇痛作用的研究

冯前进1; 王世民1; 冯玛莉2; 武玉鹏2; 杨艳华2

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理气止疼与活血止疼治则镇痛作用的比较药理学研究(Ⅰ)——失笑散与金铃子散镇痛作用的研究

更新时间：2024-01-04

- 理气止疼与活血止疼治则镇痛作用的比较药理学研究(Ⅰ)——失笑散与金铃子散镇痛作用的研究
- A study of comparative pharmacology of Regulating Vital Energy to Alleviate Pain andPromoting Blood Circulation to Stop Pain on Analgesic Effect in Mice(Ⅰ)——The analgesic effect study of Jinlingzisan and Shixiaosan
- 中国实验方剂学杂志 1999年5卷第3期页码：12-14
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- 纸质出版日期：1999
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冯前进1, 王世民1, 冯玛莉2, 等. 理气止疼与活血止疼治则镇痛作用的比较药理学研究(Ⅰ)——失笑散与金铃子散镇痛作用的研究[J]. 中国实验方剂学杂志, 1999,5(3):12-14.

Feng Qianjin, Wang Shimin, Feng Mali, et al. A study of comparative pharmacology of Regulating Vital Energy to Alleviate Pain andPromoting Blood Circulation to Stop Pain on Analgesic Effect in Mice(Ⅰ)——The analgesic effect study of Jinlingzisan and Shixiaosan[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(3): 12-14.
冯前进1, 王世民1, 冯玛莉2, 等. 理气止疼与活血止疼治则镇痛作用的比较药理学研究(Ⅰ)——失笑散与金铃子散镇痛作用的研究[J]. 中国实验方剂学杂志, 1999,5(3):12-14. DOI：

Feng Qianjin, Wang Shimin, Feng Mali, et al. A study of comparative pharmacology of Regulating Vital Energy to Alleviate Pain andPromoting Blood Circulation to Stop Pain on Analgesic Effect in Mice(Ⅰ)——The analgesic effect study of Jinlingzisan and Shixiaosan[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(3): 12-14. DOI：

摘要

用实验药理学方法

观察理气止疼方剂金铃子散和活血止疼方剂失笑散对冰醋酸?热板和甲醛-足跖炎性疼痛反应的影响?结果表明

理气止疼方剂金铃子散对冰醋酸以及甲醛-足跖炎性疼痛反应(F?S相)均有显著抑制作用

但对热刺激疼痛反应的抑制作用没有统计学差异?活血止疼方剂失笑散对冰醋酸?热板以及甲醛-足跖炎性疼痛的F相反应有显著抑制效果

但对甲醛-足跖炎性疼痛的S相反应则无显著抑制效果。

Abstract

The analgesic effect of Jinlingzisan(JLZS

a prescription for analgesic by regulation Qi) and Shixiaosan(SXS

a prescription for analgesic by activate the blood) was observed on the pain-like responses and inflammatory pain response that caused by acetic acid

heat and formalin in mice.JLZS showed a potent inhibitory activity on the acetic acid-induced writhing and formalin-induced F、S phase pain response

but heat-induced pain-like response was not inhibited significantly.SXS showed a potent inhibitory activity on the acetic acid and heat-induced pain-like response as well as the formalin-induced F phase pain response

but showed no effect significantly on the S phase pain response caused by formalin.From these results

it was concluded that analgesic mechanism of regulating vital energy to alleviate pain and promoting blood circulation to stop pain is different.

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